New Biomarker Identifies Link Between Allergic Rhinitis and Systemic Lupus Erythematosus

In a new study, researchers have identified ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1) as a novel biomarker that connects allergic rhinitis (AR, commonly known as hay fever), and systemic lupus erythematosus (SLE). AR is an allergic reaction that occurs when the immune system overreacts to airborne allergens, leading to inflammation. The findings of this study indicate that ENTPD1 could be a crucial link between AR and SLE, pointing to a shared molecular pathway which suggests these diseases may be more interconnected than previously thought. 

Study participants were divided into four groups: healthy controls (8 people), AR without SLE (9 people), SLE without AR (8 people), and SLE with AR (5 people). Each participant had their blood drawn and analyzed to screen for specific genes. The analysis revealed ENTPD1 as a hub of 11 shared genes between AR and SLE associated with immune response and inflammation. Furthermore, targeting ENTPD1 could provide a new therapeutic option to help prevent AR from developing SLE. 

Understanding the connection between AR and SLE could pave the way for research into how these diseases develop, progress, and could inform treatment options. Learn more about what causes lupus.

Read the study